Any questions about the information below, any additions or edits? Or simply interested in getting involved? Please email Dr. Marie Burdine MBurdine@uams.edu.

Lead Project Title  Description                  
David HarrisonDNA-PKcs Inhibitors as Transplant TherapyUse of pig kidney transplant model to determine the effect of DNA-PKcs inhibitors on transplant rejection
Zach WaldripCharacterizing the function of DNA-PKcs in T cell biologyUse of in vitro models and a novel mouse strain to analyze the role of DNA-PKcs in T cell activation and differentiation
Ana Azevedo-PoulyDNA-PKcs in the epigenetic regulation of cytokine transcriptionExploring the role of DNA-PKcs in regulating chromatin remodeling and transcriptional complex formation to induce cytokine production in T cells using a genomic approaches including chIP-Seq and ATAC-seq.
Ana Azevedo-PoulyThe effects of DNA-PKcs on T cell response to tumor antigensUsing a melanoma model, we are investigating how DNA-PKcs affects the response of T cells to tumors. A phospho-proteomics approach using clinical samples will allow us to identify mechanisms used by DNA-PKcs to control T cell response.
Ana Azevedo-PoulyDNA-PKcs Promotes Pancreatic Cancer MetastasisUsing in vitro and in vivo models, we are exploring the ability of DNA-PKcs to promote tumor cell EMT to drive metastasis of pancreatic cancer.
Lauren AppellDNA-PKcs inhibition prevents GVHDIn collaboration with Dr. Marjan Boerma at UAMS, we are using an murine allogeneic stem cell transplant model to determine if DNA-PKcs inhibitors can prevent GVHD.
Lauren AppellDNA-PKcs is critical for T cell differentiationUsing in vitro analysis and Flow cytometry, we are analyzing the effects of DNA-PKcs on naïve T cell differentiation into subtypes, T reg, Th17, Th1, Th2
Nadir El Sharawi (Anesthesiology)Plasma Concentration of Biological Markers in Placental Accreta SpectrumAnalyzing microparticle levels and protein concentrations by flow cytometry and mass spectrometry to identify potential markers for early placental accreta